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Alexander Hoffmann
Alexander Hoffmann is an American biologist. He is the director of the Institute for Quantitative and Computational Biosciences (OCBio) and the Thomas M Asher Professor of Microbiology in the Department of Microbiology, Immunology, and Molecular Genetics (MIMG) at the University of California, Los Angeles (UCLA). His research interest is the development of a predictive understanding of how cellular and molecular networks regulate immune responses.〔http://signalingsystems.ucla.edu〕
== Education ==
Hoffmann gained his BA in Physics and Zoology at Cambridge University in 1988, pursuing research projects under the tutelage of John Gurdon and John Lasky. He obtained his Ph.D. in Biochemistry and Molecular Biology from the Rockefeller University in 1994 under the supervision of Robert G. Roeder. Working with Roeder, Hoffmann identified genes encoding the central transcription factor TFIID, including its DNA binding subunit TATA-box binding subunit.〔Hoffmann, A., Horikoshi, M., Wang, C. K., Schroeder, S., Weil, P.A., Roeder, R.G. 1990. Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID. Genes & Development 4, pp. 1141-1148〕〔Hoffmann, A., Sinn, E., Yamamoto, T., Wang, J., Roy, A., Horikoshi, M., Roeder, R.G. 1990. Highly conserved core domain and unique N-terminus with presumptive regulatory motifs in a human TATA factor (TFIID). Nature 346, No.6282, pp.387-390〕〔Gasch, A., Hoffmann, A., Horikoshi, M., Roeder, R.G., Chua, N.H. 1990. Arabidopsis thaliana contains two genes for TFIID. Nature 346, No.6282, pp.390-394〕〔Hoffmann, A., Chiang, C.-M., Oelgeschläger, T., Burley, S.K., Nakatani, Y., Roeder, R.G. 1996 A histone octamer-like structure within TFIID. Nature 380, No.6572, pp. 356-359〕〔Hoffmann, A., Oelgeschläger, T., Roeder, R.G. 1997 Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions ? Proc. Natl. Acad. Sci. USA 94, pp. 8928-8935〕 He also developed the now popular His-tag expression system,〔Hoffmann, A. and Roeder, R.G. 1991. Purification of his-tagged proteins in non-denaturing conditions suggests a convenient method for protein interaction studies. Nucleic Acids Research 19, No.22, pp. 6337-6338〕 which facilitates the purification of recombinant proteins.〔Nikolov, D.B., Hu, S.-H., Lin, J., Gasch, A., Hoffmann, A., Horikoshi, M., Chua, N.-H., Roeder, R.G., Burley, S.K. 1992. Crystal structure of TFIID TATA-box binding protein. Nature 360, pp. 40-46〕〔Xie, X.-L., Kokubo, T., Cohen, S., Mirza, U.A., Hoffmann, A., Chait, B.T., Roeder, R.G., Nakatani, Y., Burley, S.K. 1996 Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Nature 380, No.6572, pp. 316-322.〕
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